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Glynn and Holborow had been more productive in a restricted experiment with heterologous chondroitin derived from human cartilage, but repetition of the practically identical experiment by Boake and Muir yielded no proof of arthritis when rabbits were injected with homologous chondroitin and killed streptococci.
 The benefits of Glynn and Holborow have been attributed to the presence in the antigen of traces of heterologous protein. Renewed interest in the difficulty of producing an homologous tissue arthritis was aroused by the report of Stoerk, Bielinski, and Budzilovich. These authors claimed to have developed a continual polyarthritis in rats by injecting homologous spleen and adjuvants. Antibiotics did not impact the persistence of the lesions and repeated cultures grew no P. P. L. O. This work has not been confirmed.

Fairly equivalent experiments, repeated unsuccessfully by the reviewer, had been described by Pearson, who claimed to have created joint and other lesions with injections of homologous muscle and adjuvants. This mindful function was followed Topoisomerase by an admission that equivalent joint lesions could be elicited by injecting Freunds adjuvants with out muscle. Despite the fact that P. P. L. O. had been recovered from numerous of the authentic animals, these organisms were not believed to be accountable for the arthritis. Odell and Essential employed egg albumen as antigen with Freunds adjuvants in similar operate in the rabbit, they confirmed that adjuvants alone triggered a far more serious arthritic reaction than when mixed with antigen. Injection of Anti bomologous Tissue Antisera.

Favour, Goldthwait, and Bayles reported the injection of cell totally free saline extracts of guinea pig synovia into rabbits. They subsequently PDK 1 Signaling injected into guinea pigs the rabbit anti guinea pig synovia serum obtained in this way, right after labelling with 1311. No antibody localization in the joints was detected nor was there histological proof of synovial lesions. Nearby Injection followed by Systemic Injection of Antigenic Materials. Faber described the injection of rabbit knee joints with killed streptococci, 14 to 65 days later on a more, intravenous injection was created. Gross lesions developed only when further intravenous injections have been given. Kinsella and Hagebush, making use of a freeze dried preparation of streptococci in the identical manner, developed an allergic arthritis. Moritz and Morley injected bacterial filtrates from B.

coli and B. typhosus into rabbit knee joints, and cutaneous injections were given synchronously, HSP 20 to 30 hrs later on intravenous injections of the very same antigen had been created. 6 of eleven animals showed a synovial reaction, with endovascular damage, thrombosis, and vascular necrosis. Other Observations on Sensitization to Foreign Material. Jones, Carter, and Rankin emphasized that the capability of a series of injections of the polysaccharides extracted from Friedlanders Topoisomerase bacillus to cause joint alterations was a measure neither of the anaphylactogenic nature of the extract, nor of its nitrogen or protein content. In the guinea pig there was no correlation amongst the occurrence of cardiac or of joint lesions, the alterations created by mucopolysaccharides from a variety of sources were non specific.