15 cdk1 inhibitor Cell Cycle inhibitor Myths Disclosed

Accumulating evidence suggests that the transcription factor NF kB is a vital intracellular mediator initiating the cascade cdk1 inhibitor of events that result in b cell death inside the presence of cytokines.



These results suggest that increased NF kB activation and NO production in PancMet KO islets affect cytokine induced but not Fas/FasL or STZmediated b cell death, and that proapoptotic genes induced by NF kB counteract the potential prosurvival Cell Cycle inhibitor effects of A20 in c Met null b cells. HGF decreases NF kB activation and protects rodent and human b cells against cytokines. To ascertain whether activation of the HGF/c Met signaling pathway protects b cells from cytokines, we added HGF to normal mouse primary islet cell cultures treated with increasing doses of cytokines and analyzed the percentage of TUNEL positive b cells. HGF completely protected normal mouse b cells against cytokines, but not PancMet KO b cells, suggesting that HGF induced protective effects are mediated through c Met.

Taken together, these results suggest that HGF may protect human b cells against cytokine induced cell death by inactivation of the NF kB and activation of the PI3K/Akt signaling pathways.

On the other hand, HGF protects rodent and, more important, human b cells from cytokine induced cell death.